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2b2r

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[[Image:2b2r.gif|left|200px]]<br /><applet load="2b2r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2b2r.gif|left|200px]]
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caption="2b2r, resolution 1.90&Aring;" />
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'''Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6'''<br />
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{{Structure
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|PDB= 2b2r |SIZE=350|CAPTION= <scene name='initialview01'>2b2r</scene>, resolution 1.90&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=O:OXYGEN ATOM'>O</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6]
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|GENE= katG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])
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}}
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'''Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2B2R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=O:'>O</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2R OCA].
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2B2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2R OCA].
==Reference==
==Reference==
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A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16211084 16211084]
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A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16211084 16211084]
[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
[[Category: Catalase]]
[[Category: Catalase]]
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[[Category: oxoferryl species]]
[[Category: oxoferryl species]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:56:50 2008''

Revision as of 13:56, 20 March 2008

Image:2b2r.gif


PDB ID 2b2r

Drag the structure with the mouse to rotate
, resolution 1.90Å
Ligands: , and
Gene: katG (Burkholderia pseudomallei)
Activity: Catalase, with EC number 1.11.1.6
Coordinates: save as pdb, mmCIF, xml



Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6


Overview

The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.

About this Structure

2B2R is a Single protein structure of sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.

Reference

A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084

Page seeded by OCA on Thu Mar 20 15:56:50 2008

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