2b2r
From Proteopedia
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| - | [[Image:2b2r.gif|left|200px]] | + | [[Image:2b2r.gif|left|200px]] |
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| - | '''Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6''' | + | {{Structure |
| + | |PDB= 2b2r |SIZE=350|CAPTION= <scene name='initialview01'>2b2r</scene>, resolution 1.90Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=O:OXYGEN ATOM'>O</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] | ||
| + | |GENE= katG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2B2R is a [ | + | 2B2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2R OCA]. |
==Reference== | ==Reference== | ||
| - | A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:[http:// | + | A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16211084 16211084] |
[[Category: Burkholderia pseudomallei]] | [[Category: Burkholderia pseudomallei]] | ||
[[Category: Catalase]] | [[Category: Catalase]] | ||
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[[Category: oxoferryl species]] | [[Category: oxoferryl species]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:56:50 2008'' |
Revision as of 13:56, 20 March 2008
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| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Gene: | katG (Burkholderia pseudomallei) | ||||||
| Activity: | Catalase, with EC number 1.11.1.6 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6
Overview
The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.
About this Structure
2B2R is a Single protein structure of sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.
Reference
A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084
Page seeded by OCA on Thu Mar 20 15:56:50 2008
Categories: Burkholderia pseudomallei | Catalase | Single protein | Carpena, X. | Deemagarn, T. | Fita, I. | Ivancich, A. | Loewen, P C. | Singh, R. | Switala, J. | Wiseman, B. | HEM | NA | O | Catalase-peroxidase | Compound i | Katg | Oxoferryl species
