1l2m
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1l2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tomato_yellow_leaf_curl_sardinia_virus Tomato yellow leaf curl sardinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2M FirstGlance]. <br> | <table><tr><td colspan='2'>[[1l2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tomato_yellow_leaf_curl_sardinia_virus Tomato yellow leaf curl sardinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L2M FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l5i|1l5i]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l5i|1l5i]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rep ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=123735 Tomato yellow leaf curl Sardinia virus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rep ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=123735 Tomato yellow leaf curl Sardinia virus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2m RCSB], [http://www.ebi.ac.uk/pdbsum/1l2m PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l2m RCSB], [http://www.ebi.ac.uk/pdbsum/1l2m PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/REP_TYCSV REP_TYCSV]] Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific region at the genome origin of replication. It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Tomato yellow leaf curl sardinia virus]] | [[Category: Tomato yellow leaf curl sardinia virus]] | ||
| - | [[Category: Campos-Olivas, R | + | [[Category: Campos-Olivas, R]] |
| - | [[Category: Clerot, D | + | [[Category: Clerot, D]] |
| - | [[Category: Gronenborn, A M | + | [[Category: Gronenborn, A M]] |
| - | [[Category: Gronenborn, B | + | [[Category: Gronenborn, B]] |
| - | [[Category: Louis, J M | + | [[Category: Louis, J M]] |
[[Category: A+b fold]] | [[Category: A+b fold]] | ||
[[Category: Rbd-like fold]] | [[Category: Rbd-like fold]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 02:43, 25 December 2014
Minimized Average Structure of the N-terminal, DNA-binding domain of the replication initiation protein from a geminivirus (Tomato yellow leaf curl virus-Sardinia)
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