This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2z4w
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2z4w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4W FirstGlance]. <br> | <table><tr><td colspan='2'>[[2z4w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z4W FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=749:[(6E,11E)-2,6,12,16-TETRAMETHYLHEPTADECA-2,6,11,15-TETRAENE-9,9-DIYL]BIS(PHOSPHONIC+ACID)'>749</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=749:[(6E,11E)-2,6,12,16-TETRAMETHYLHEPTADECA-2,6,11,15-TETRAENE-9,9-DIYL]BIS(PHOSPHONIC+ACID)'>749</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2z4v|2z4v]], [[2z4x|2z4x]], [[2z4y|2z4y]], [[2z4z|2z4z]], [[2z50|2z50]], [[2z52|2z52]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2z4v|2z4v]], [[2z4x|2z4x]], [[2z4y|2z4y]], [[2z4z|2z4z]], [[2z50|2z50]], [[2z52|2z52]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4w RCSB], [http://www.ebi.ac.uk/pdbsum/2z4w PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z4w RCSB], [http://www.ebi.ac.uk/pdbsum/2z4w PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST]] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Cao, R | + | [[Category: Cao, R]] |
| - | [[Category: Chen, C K.M | + | [[Category: Chen, C K.M]] |
| - | [[Category: Guo, R T | + | [[Category: Guo, R T]] |
| - | [[Category: Hudock, M | + | [[Category: Hudock, M]] |
| - | [[Category: Oldfield, E | + | [[Category: Oldfield, E]] |
| - | [[Category: Wang, A H.J | + | [[Category: Wang, A H.J]] |
[[Category: Bisphosphonate]] | [[Category: Bisphosphonate]] | ||
[[Category: Geranylgeranyl pyrophosphate]] | [[Category: Geranylgeranyl pyrophosphate]] | ||
Revision as of 02:43, 25 December 2014
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-749
| |||||||||||
