2xru
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [http://www.ebi.ac.uk/pdbsum/2xru PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [http://www.ebi.ac.uk/pdbsum/2xru PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/STK6_HUMAN STK6_HUMAN]] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| - | [[Category: Alli, C | + | [[Category: Alli, C]] |
| - | [[Category: Anello, M D | + | [[Category: Anello, M D]] |
| - | [[Category: Berta, D | + | [[Category: Berta, D]] |
| - | [[Category: Bertrand, J A | + | [[Category: Bertrand, J A]] |
| - | [[Category: Bindi, S | + | [[Category: Bindi, S]] |
| - | [[Category: Cameron, A D | + | [[Category: Cameron, A D]] |
| - | [[Category: Cappella, P | + | [[Category: Cappella, P]] |
| - | [[Category: Carpinelli, P | + | [[Category: Carpinelli, P]] |
| - | [[Category: Cervi, G | + | [[Category: Cervi, G]] |
| - | [[Category: Croci, W | + | [[Category: Croci, W]] |
| - | [[Category: Fancelli, D | + | [[Category: Fancelli, D]] |
| - | [[Category: Forte, B | + | [[Category: Forte, B]] |
| - | [[Category: Lauragiorgini, M | + | [[Category: Lauragiorgini, M]] |
| - | [[Category: Marsiglio, A | + | [[Category: Marsiglio, A]] |
| - | [[Category: Moll, J | + | [[Category: Moll, J]] |
| - | [[Category: Pesenti, E | + | [[Category: Pesenti, E]] |
| - | [[Category: Pittala, V | + | [[Category: Pittala, V]] |
| - | [[Category: Pulici, M | + | [[Category: Pulici, M]] |
| - | [[Category: Riccardi-Sirtori, F | + | [[Category: Riccardi-Sirtori, F]] |
| - | [[Category: Roletto, F | + | [[Category: Roletto, F]] |
| - | [[Category: Soncini, C | + | [[Category: Soncini, C]] |
| - | [[Category: Storici, P | + | [[Category: Storici, P]] |
| - | [[Category: Varasi, M | + | [[Category: Varasi, M]] |
| - | [[Category: Vianello, P | + | [[Category: Vianello, P]] |
| - | [[Category: Volpi, D | + | [[Category: Volpi, D]] |
| - | [[Category: Zugnoni, P | + | [[Category: Zugnoni, P]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 02:47, 25 December 2014
AURORA-A T288E COMPLEXED WITH PHA-828300
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Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Alli, C | Anello, M D | Berta, D | Bertrand, J A | Bindi, S | Cameron, A D | Cappella, P | Carpinelli, P | Cervi, G | Croci, W | Fancelli, D | Forte, B | Lauragiorgini, M | Marsiglio, A | Moll, J | Pesenti, E | Pittala, V | Pulici, M | Riccardi-Sirtori, F | Roletto, F | Soncini, C | Storici, P | Varasi, M | Vianello, P | Volpi, D | Zugnoni, P | Cell cycle | Kinase | Nucleotide-binding | Transferase
