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4atx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4atx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ATX FirstGlance]. <br> | <table><tr><td colspan='2'>[[4atx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ATX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jff|1jff]], [[1sa0|1sa0]], [[1sa1|1sa1]], [[1tvk|1tvk]], [[1z2b|1z2b]], [[2wbe|2wbe]], [[2xrp|2xrp]], [[4aqv|4aqv]], [[4aqw|4aqw]], [[4atu|4atu]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jff|1jff]], [[1sa0|1sa0]], [[1sa1|1sa1]], [[1tvk|1tvk]], [[1z2b|1z2b]], [[2wbe|2wbe]], [[2xrp|2xrp]], [[4aqv|4aqv]], [[4aqw|4aqw]], [[4atu|4atu]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulin_GTPase Tubulin GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.6 3.6.5.6] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4atx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4atx RCSB], [http://www.ebi.ac.uk/pdbsum/4atx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4atx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4atx RCSB], [http://www.ebi.ac.uk/pdbsum/4atx PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/KINH_RAT KINH_RAT]] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).[UniProtKB:Q61768] [[http://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Tubulin GTPase]] | [[Category: Tubulin GTPase]] | ||
| - | [[Category: Fourniol, F J | + | [[Category: Fourniol, F J]] |
| - | [[Category: Fu, X | + | [[Category: Fu, X]] |
| - | [[Category: Houdusse, A | + | [[Category: Houdusse, A]] |
| - | [[Category: Jaiswal, J K | + | [[Category: Jaiswal, J K]] |
| - | [[Category: Liu, J S | + | [[Category: Liu, J S]] |
| - | [[Category: Moores, C A | + | [[Category: Moores, C A]] |
| - | [[Category: Schubert, C R | + | [[Category: Schubert, C R]] |
| - | [[Category: Stultz, C M | + | [[Category: Stultz, C M]] |
| - | [[Category: Walsh, C A | + | [[Category: Walsh, C A]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Microtubule]] | [[Category: Microtubule]] | ||
[[Category: Neck-linker]] | [[Category: Neck-linker]] | ||
Revision as of 02:49, 25 December 2014
Rigor kinesin motor domain with an ordered neck-linker, docked on tubulin dimer, modelled into the 8A cryo-EM map of doublecortin- microtubules decorated with kinesin
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Categories: Bos taurus | Rattus norvegicus | Tubulin GTPase | Fourniol, F J | Fu, X | Houdusse, A | Jaiswal, J K | Liu, J S | Moores, C A | Schubert, C R | Stultz, C M | Walsh, C A | Hydrolase | Microtubule | Neck-linker
