2b48

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[[Image:2b48.gif|left|200px]]<br /><applet load="2b48" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2b48.gif|left|200px]]
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caption="2b48, resolution 3.45&Aring;" />
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'''Bcl-XL 3D Domain Swapped Dimer'''<br />
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{{Structure
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|PDB= 2b48 |SIZE=350|CAPTION= <scene name='initialview01'>2b48</scene>, resolution 3.45&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Bcl-XL 3D Domain Swapped Dimer'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2B48 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B48 OCA].
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2B48 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B48 OCA].
==Reference==
==Reference==
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BCL-XL dimerization by three-dimensional domain swapping., O'Neill JW, Manion MK, Maguire B, Hockenbery DM, J Mol Biol. 2006 Feb 17;356(2):367-81. Epub 2005 Dec 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16368107 16368107]
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BCL-XL dimerization by three-dimensional domain swapping., O'Neill JW, Manion MK, Maguire B, Hockenbery DM, J Mol Biol. 2006 Feb 17;356(2):367-81. Epub 2005 Dec 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16368107 16368107]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: dimeric]]
[[Category: dimeric]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:57:22 2008''

Revision as of 13:57, 20 March 2008

Image:2b48.gif


PDB ID 2b48

Drag the structure with the mouse to rotate
, resolution 3.45Å
Gene: BCL2L1, BCL2L, BCLX (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Bcl-XL 3D Domain Swapped Dimer


Overview

Dimeric interactions among anti- and pro-apoptotic members of the BCL-2 protein family are dynamically regulated and intimately involved in survival and death functions. We report the structure of a BCL-X(L) homodimers a 3D-domain swapped dimer (3DDS). The X-ray crystal structure demonstrates the mutual exchange of carboxy-terminal regions including BH2 (Bcl-2 homology 2) between monomer subunits, with the hinge region occurring at the hairpin turn between the fifth and sixth alpha helices. Both BH3 peptide-binding hydrophobic grooves are unoccupied in the 3DDS dimer and available for BH3 peptide binding, as confirmed by sedimentation velocity analysis. BCL-X(L) 3DDS dimers have increased pore-forming activity compared to monomers, suggesting that 3DDS dimers may act as intermediates in membrane pore formation. Chemical crosslinking studies of Cys-substituted BCL-X(L) proteins demonstrate that 3DDS dimers form in synthetic lipid vesicles.

About this Structure

2B48 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

BCL-XL dimerization by three-dimensional domain swapping., O'Neill JW, Manion MK, Maguire B, Hockenbery DM, J Mol Biol. 2006 Feb 17;356(2):367-81. Epub 2005 Dec 1. PMID:16368107

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