2b6b
From Proteopedia
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| - | [[Image:2b6b.gif|left|200px]] | + | [[Image:2b6b.gif|left|200px]] |
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| - | '''Cryo EM structure of Dengue complexed with CRD of DC-SIGN''' | + | {{Structure |
| + | |PDB= 2b6b |SIZE=350|CAPTION= <scene name='initialview01'>2b6b</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CD209 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Cryo EM structure of Dengue complexed with CRD of DC-SIGN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2B6B is a [ | + | 2B6B is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6B OCA]. |
==Reference== | ==Reference== | ||
| - | Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN., Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG, Cell. 2006 Feb 10;124(3):485-93. PMID:[http:// | + | Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN., Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG, Cell. 2006 Feb 10;124(3):485-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16469696 16469696] |
[[Category: Dengue virus]] | [[Category: Dengue virus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:58:09 2008'' |
Revision as of 13:58, 20 March 2008
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| Gene: | CD209 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Cryo EM structure of Dengue complexed with CRD of DC-SIGN
Overview
Dengue virus (DENV) is a significant human pathogen that causes millions of infections and results in about 24,000 deaths each year. Dendritic cell-specific ICAM3 grabbing nonintegrin (DC-SIGN), abundant in immature dendritic cells, was previously reported as being an ancillary receptor interacting with the surface of DENV. The structure of DENV in complex with the carbohydrate recognition domain (CRD) of DC-SIGN was determined by cryo-electron microscopy at 25 A resolution. One CRD monomer was found to bind to two glycosylation sites at Asn67 of two neighboring glycoproteins in each icosahedral asymmetric unit, leaving the third Asn67 residue vacant. The vacancy at the third Asn67 site is a result of the nonequivalence of the glycoprotein environments, leaving space for the primary receptor binding to domain III of E. The use of carbohydrate moieties for receptor binding sites suggests a mechanism for avoiding immune surveillance.
About this Structure
2B6B is a Protein complex structure of sequences from Dengue virus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN., Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG, Cell. 2006 Feb 10;124(3):485-93. PMID:16469696
Page seeded by OCA on Thu Mar 20 15:58:09 2008
