2b7m
From Proteopedia
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| - | [[Image:2b7m.gif|left|200px]] | + | [[Image:2b7m.gif|left|200px]] |
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| - | '''Crystal Structure of the S. cerevisiae Exocyst Component Exo70p''' | + | {{Structure |
| + | |PDB= 2b7m |SIZE=350|CAPTION= <scene name='initialview01'>2b7m</scene>, resolution 3.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= EXO70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of the S. cerevisiae Exocyst Component Exo70p''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2B7M is a [ | + | 2B7M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7M OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the S.cerevisiae exocyst component Exo70p., Hamburger ZA, Hamburger AE, West AP Jr, Weis WI, J Mol Biol. 2006 Feb 10;356(1):9-21. Epub 2005 Nov 10. PMID:[http:// | + | Crystal structure of the S.cerevisiae exocyst component Exo70p., Hamburger ZA, Hamburger AE, West AP Jr, Weis WI, J Mol Biol. 2006 Feb 10;356(1):9-21. Epub 2005 Nov 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16359701 16359701] |
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: exocytosis]] | [[Category: exocytosis]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:58:34 2008'' |
Revision as of 13:58, 20 March 2008
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| , resolution 3.50Å | |||||||
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| Gene: | EXO70 (Saccharomyces cerevisiae) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the S. cerevisiae Exocyst Component Exo70p
Overview
The exocyst is an evolutionarily conserved multiprotein complex required for the targeting and docking of post-Golgi vesicles to the plasma membrane. Through its interactions with a variety of proteins, including small GTPases, the exocyst is thought to integrate signals from the cell and signal that vesicles arriving at the plasma membrane are ready for fusion. Here we describe the three-dimensional crystal structure of one of the components of the exocyst, Exo70p, from Saccharomyces cerevisiae at 3.5A resolution. Exo70p binds the small GTPase Rho3p in a GTP-dependent manner with an equilibrium dissociation constant of approximately 70 microM. Exo70p is an extended rod approximately 155 angstroms in length composed principally of alpha helices, and is a novel fold. The structure provides a first view of the Exo70 protein family and provides a framework to study the molecular function of this exocyst component.
About this Structure
2B7M is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structure of the S.cerevisiae exocyst component Exo70p., Hamburger ZA, Hamburger AE, West AP Jr, Weis WI, J Mol Biol. 2006 Feb 10;356(1):9-21. Epub 2005 Nov 10. PMID:16359701
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