2b9l
From Proteopedia
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| - | [[Image:2b9l.gif|left|200px]] | + | [[Image:2b9l.gif|left|200px]] |
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| - | '''Crystal structure of prophenoloxidase activating factor-II from the beetle Holotrichia diomphalia''' | + | {{Structure |
| + | |PDB= 2b9l |SIZE=350|CAPTION= <scene name='initialview01'>2b9l</scene>, resolution 2.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of prophenoloxidase activating factor-II from the beetle Holotrichia diomphalia''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2B9L is a [ | + | 2B9L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Holotrichia_diomphalia Holotrichia diomphalia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9L OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a clip-domain serine protease and functional roles of the clip domains., Piao S, Song YL, Kim JH, Park SY, Park JW, Lee BL, Oh BH, Ha NC, EMBO J. 2005 Dec 21;24(24):4404-14. Epub 2005 Dec 15. PMID:[http:// | + | Crystal structure of a clip-domain serine protease and functional roles of the clip domains., Piao S, Song YL, Kim JH, Park SY, Park JW, Lee BL, Oh BH, Ha NC, EMBO J. 2005 Dec 21;24(24):4404-14. Epub 2005 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16362048 16362048] |
[[Category: Holotrichia diomphalia]] | [[Category: Holotrichia diomphalia]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: melanin]] | [[Category: melanin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:59:12 2008'' |
Revision as of 13:59, 20 March 2008
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| , resolution 2.00Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of prophenoloxidase activating factor-II from the beetle Holotrichia diomphalia
Overview
Clip-domain serine proteases (SPs) are the essential components of extracellular signaling cascades in various biological processes, especially in embryonic development and the innate immune responses of invertebrates. They consist of a chymotrypsin-like SP domain and one or two clip domains at the N-terminus. Prophenoloxidase-activating factor (PPAF)-II, which belongs to the noncatalytic clip-domain SP family, is indispensable for the generation of the active phenoloxidase leading to melanization, a major defense mechanism of insects. Here, the crystal structure of PPAF-II reveals that the clip domain adopts a novel fold containing a central cleft, which is distinct from the structures of defensins with a similar arrangement of cysteine residues. Ensuing studies demonstrated that PPAF-II forms a homo-oligomer upon cleavage by the upstream protease and that the clip domain of PPAF-II functions as a module for binding phenoloxidase through the central cleft, while the clip domain of a catalytically active easter-type SP plays an essential role in the rapid activation of its protease domain.
About this Structure
2B9L is a Single protein structure of sequence from Holotrichia diomphalia. Full crystallographic information is available from OCA.
Reference
Crystal structure of a clip-domain serine protease and functional roles of the clip domains., Piao S, Song YL, Kim JH, Park SY, Park JW, Lee BL, Oh BH, Ha NC, EMBO J. 2005 Dec 21;24(24):4404-14. Epub 2005 Dec 15. PMID:16362048
Page seeded by OCA on Thu Mar 20 15:59:12 2008
Categories: Holotrichia diomphalia | Single protein | Ha, N C. | Lee, B L. | Oh, B H. | Park, S Y. | Piao, S. | Song, Y L. | CA | SO4 | Clip domain | Easter | Innate immunity | Melanin
