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1x67
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1x67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X67 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1x67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X67 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DBNL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DBNL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x67 RCSB], [http://www.ebi.ac.uk/pdbsum/1x67 PDBsum], [http://www.topsan.org/Proteins/RSGI/1x67 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x67 RCSB], [http://www.ebi.ac.uk/pdbsum/1x67 PDBsum], [http://www.topsan.org/Proteins/RSGI/1x67 TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DBNL_HUMAN DBNL_HUMAN]] Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin.<ref>PMID:14729663</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Goroncy, A K | + | [[Category: Goroncy, A K]] |
| - | [[Category: Inoue, M | + | [[Category: Inoue, M]] |
| - | [[Category: Kigawa, T | + | [[Category: Kigawa, T]] |
| - | [[Category: Kobayashi, N | + | [[Category: Kobayashi, N]] |
| - | [[Category: Koshiba, S | + | [[Category: Koshiba, S]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Sato, M | + | [[Category: Sato, M]] |
| - | [[Category: Tochio, N | + | [[Category: Tochio, N]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
[[Category: Actin-binding protein]] | [[Category: Actin-binding protein]] | ||
[[Category: C-jun n-terminal kinase activation]] | [[Category: C-jun n-terminal kinase activation]] | ||
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[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Sh3p7]] | [[Category: Sh3p7]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: T-cell antigen receptor regulation]] | [[Category: T-cell antigen receptor regulation]] | ||
[[Category: T-cell lymphocyte signaling and regulation]] | [[Category: T-cell lymphocyte signaling and regulation]] | ||
Revision as of 03:27, 25 December 2014
Solution structure of the cofilin homology domain of HIP-55 (drebrin-like protein)
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Categories: Homo sapiens | Goroncy, A K | Inoue, M | Kigawa, T | Kobayashi, N | Koshiba, S | Structural genomic | Sato, M | Tochio, N | Yokoyama, S | Actin-binding protein | C-jun n-terminal kinase activation | Cell-free protein synthesis | Hpk-1 activation | Mabp1 | National project on protein structural and functional analyse | Nppsfa | Protein binding | Rsgi | Sh3p7 | T-cell antigen receptor regulation | T-cell lymphocyte signaling and regulation
