2bat
From Proteopedia
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| - | [[Image:2bat.gif|left|200px]] | + | [[Image:2bat.gif|left|200px]] |
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| - | '''THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR''' | + | {{Structure |
| + | |PDB= 2bat |SIZE=350|CAPTION= <scene name='initialview01'>2bat</scene>, resolution 2.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BAT is a [ | + | 2BAT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAT OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor., Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM, Proteins. 1992 Nov;14(3):327-32. PMID:[http:// | + | The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor., Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM, Proteins. 1992 Nov;14(3):327-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1438172 1438172] |
[[Category: Exo-alpha-sialidase]] | [[Category: Exo-alpha-sialidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: hydrolase(o-glycosyl)]] | [[Category: hydrolase(o-glycosyl)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:59:31 2008'' |
Revision as of 13:59, 20 March 2008
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| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Activity: | Exo-alpha-sialidase, with EC number 3.2.1.18 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR
Overview
Crystallographic studies of neuraminidase-sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Three arginine residues on the enzyme interact with the carboxylate group of the sugar which is observed to be equatorial to the saccharide ring as a consequence of its distorted geometry. The glycosidic oxygen is positioned within hydrogen-bonding distance of Asp-151, implicating this residue in catalysis.
About this Structure
2BAT is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor., Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM, Proteins. 1992 Nov;14(3):327-32. PMID:1438172
Page seeded by OCA on Thu Mar 20 15:59:31 2008
