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1e5d

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(New page: 200px<br /> <applet load="1e5d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e5d, resolution 2.50&Aring;" /> '''RUBREDOXIN OXYGEN:O...)
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Revision as of 14:50, 29 October 2007

Image:1e5d.gif

1e5d, resolution 2.50Å

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RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS

Overview

Desulfovibrio gigas is a strict anaerobe that contains a, well-characterized metabolic pathway that enables it to survive transient, contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct, and safe way. The 2.5 A resolution crystal structure of ROO shows that, each monomer of this homodimeric enzyme consists of a novel combination of, two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain, that contains a di-iron center for dioxygen reduction. This is the first, structure of a member of a superfamily of enzymes widespread in strict and, facultative anaerobes, indicating its broad physiological significance.

About this Structure

1E5D is a [Single protein] structure of sequence from [Desulfovibrio gigas] with FMN, FEO and OXY as [ligands]. Full crystallographic information is available from [OCA].

Reference

Structure of a dioxygen reduction enzyme from Desulfovibrio gigas., Frazao C, Silva G, Gomes CM, Matias P, Coelho R, Sieker L, Macedo S, Liu MY, Oliveira S, Teixeira M, Xavier AV, Rodrigues-Pousada C, Carrondo MA, Le Gall J, Nat Struct Biol. 2000 Nov;7(11):1041-5. PMID:11062560

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