3iqq

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iqq RCSB], [http://www.ebi.ac.uk/pdbsum/3iqq PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iqq RCSB], [http://www.ebi.ac.uk/pdbsum/3iqq PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 03:37, 25 December 2014

X-ray structure of bovine TRTK12-Ca(2+)-S100B

3iqq, resolution 2.01Å

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