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4p08
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4p08]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P08 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4p08]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P08 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cocaine_esterase Cocaine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.84 3.1.1.84] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cocaine_esterase Cocaine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.84 3.1.1.84] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p08 RCSB], [http://www.ebi.ac.uk/pdbsum/4p08 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p08 RCSB], [http://www.ebi.ac.uk/pdbsum/4p08 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM]] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Cocaine esterase]] | [[Category: Cocaine esterase]] | ||
| - | [[Category: Chow, K M | + | [[Category: Chow, K M]] |
| - | [[Category: Fang, L | + | [[Category: Fang, L]] |
| - | [[Category: Rodgers, D W | + | [[Category: Rodgers, D W]] |
| - | [[Category: Zhan, C G | + | [[Category: Zhan, C G]] |
[[Category: Cocaine]] | [[Category: Cocaine]] | ||
[[Category: Disulfide-linked dimer]] | [[Category: Disulfide-linked dimer]] | ||
Revision as of 03:37, 25 December 2014
Engineered thermostable dimeric cocaine esterase
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Categories: Cocaine esterase | Chow, K M | Fang, L | Rodgers, D W | Zhan, C G | Cocaine | Disulfide-linked dimer | Esterase | Hydrolase | Mutant
