2z0l
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2z0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z0L FirstGlance]. <br> | <table><tr><td colspan='2'>[[2z0l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z0L FirstGlance]. <br> | ||
- | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
- | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
- | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z0l RCSB], [http://www.ebi.ac.uk/pdbsum/2z0l PDBsum], [http://www.topsan.org/Proteins/RSGI/2z0l TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z0l RCSB], [http://www.ebi.ac.uk/pdbsum/2z0l PDBsum], [http://www.topsan.org/Proteins/RSGI/2z0l TOPSAN]</span></td></tr> |
- | <table> | + | </table> |
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/EAD_EBV EAD_EBV]] Plays an essential role in the viral lytic DNA replication by acting as the polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template. In addition, BMRF1 transcriptionally activates the early BHLF1 promoter.<ref>PMID:8764021</ref> <ref>PMID:16641300</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human herpesvirus 4]] | [[Category: Human herpesvirus 4]] | ||
- | [[Category: Kato-Murayama, M | + | [[Category: Kato-Murayama, M]] |
- | [[Category: Murayama, K | + | [[Category: Murayama, K]] |
- | [[Category: | + | [[Category: Structural genomic]] |
- | [[Category: Shirouzu, M | + | [[Category: Shirouzu, M]] |
- | [[Category: Terada, T | + | [[Category: Terada, T]] |
- | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
[[Category: Activator]] | [[Category: Activator]] | ||
[[Category: Alpha/beta protein]] | [[Category: Alpha/beta protein]] | ||
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[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Replication]] | [[Category: Replication]] | ||
- | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
- | [[Category: Structural genomic]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] |
Revision as of 04:05, 25 December 2014
Crystal structure of EBV-DNA polymerase accessory protein BMRF1
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Categories: Human herpesvirus 4 | Kato-Murayama, M | Murayama, K | Structural genomic | Shirouzu, M | Terada, T | Yokoyama, S | Activator | Alpha/beta protein | Dna-binding | Early protein | National project on protein structural and functional analyse | Nppsfa | Nucleus | Replication | Rsgi | Transcription | Transcription regulation