1syh
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1syh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SYH FirstGlance]. <br> | <table><tr><td colspan='2'>[[1syh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SYH FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPW:(S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL)+PROIONIC+ACID'>CPW</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPW:(S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL)+PROIONIC+ACID'>CPW</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ftj|1ftj]], [[1ftm|1ftm]], [[1fw0|1fw0]], [[1gr2|1gr2]], [[1m5b|1m5b]], [[1m5c|1m5c]], [[1m5e|1m5e]], [[1mqd|1mqd]], [[1mqg|1mqg]], [[1nnp|1nnp]], [[1syi|1syi]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ftj|1ftj]], [[1ftm|1ftm]], [[1fw0|1fw0]], [[1gr2|1gr2]], [[1m5b|1m5b]], [[1m5c|1m5c]], [[1m5e|1m5e]], [[1mqd|1mqd]], [[1mqg|1mqg]], [[1nnp|1nnp]], [[1syi|1syi]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1syh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1syh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1syh RCSB], [http://www.ebi.ac.uk/pdbsum/1syh PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1syh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1syh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1syh RCSB], [http://www.ebi.ac.uk/pdbsum/1syh PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Campiani, G | + | [[Category: Campiani, G]] |
| - | [[Category: Frandsen, A | + | [[Category: Frandsen, A]] |
| - | [[Category: Gajhede, M | + | [[Category: Gajhede, M]] |
| - | [[Category: Greenwood, J R | + | [[Category: Greenwood, J R]] |
| - | [[Category: Kasper, C | + | [[Category: Kasper, C]] |
| - | [[Category: Kastrup, J S | + | [[Category: Kastrup, J S]] |
| - | [[Category: Nielsen, B B | + | [[Category: Nielsen, B B]] |
| - | [[Category: Pickering, D S | + | [[Category: Pickering, D S]] |
| - | [[Category: Schousboe, A | + | [[Category: Schousboe, A]] |
| - | [[Category: Vestergaard, B | + | [[Category: Vestergaard, B]] |
[[Category: Agonist complex]] | [[Category: Agonist complex]] | ||
[[Category: Ionotropic glutamate receptor glur2]] | [[Category: Ionotropic glutamate receptor glur2]] | ||
[[Category: Ligand-binding core]] | [[Category: Ligand-binding core]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 04:08, 25 December 2014
X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION.
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