2kwh
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kwh RCSB], [http://www.ebi.ac.uk/pdbsum/2kwh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kwh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kwh RCSB], [http://www.ebi.ac.uk/pdbsum/2kwh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RBP1_HUMAN RBP1_HUMAN]] Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.<ref>PMID:7673236</ref> <ref>PMID:12775724</ref> <ref>PMID:11437348</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Camonis, J | + | [[Category: Camonis, J]] |
| - | [[Category: Campbell, L J | + | [[Category: Campbell, L J]] |
| - | [[Category: Fenwick, R B | + | [[Category: Fenwick, R B]] |
| - | [[Category: Mott, H R | + | [[Category: Mott, H R]] |
| - | [[Category: Nietlispach, D | + | [[Category: Nietlispach, D]] |
| - | [[Category: Owen, D | + | [[Category: Owen, D]] |
| - | [[Category: Prasannan, S | + | [[Category: Prasannan, S]] |
| - | [[Category: Rajasekar, K | + | [[Category: Rajasekar, K]] |
[[Category: Gtpase activation]] | [[Category: Gtpase activation]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 04:14, 25 December 2014
Ral binding domain of RLIP76 (RalBP1)
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