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2bm2

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bm2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BM2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bm2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BM2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PM2:1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE'>PM2</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PM2:1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE'>PM2</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a0l|1a0l]], [[1aao|1aao]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a0l|1a0l]], [[1aao|1aao]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bm2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bm2 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bm2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bm2 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Tryptase]]
[[Category: Tryptase]]
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[[Category: Aldous, S.]]
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[[Category: Aldous, S]]
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[[Category: Astles, P.]]
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[[Category: Astles, P]]
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[[Category: Cairns, J.]]
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[[Category: Cairns, J]]
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[[Category: Czekaj, M.]]
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[[Category: Czekaj, M]]
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[[Category: Davidson, J.]]
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[[Category: Davidson, J]]
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[[Category: Dupuy, A.]]
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[[Category: Dupuy, A]]
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[[Category: Eastwood, P.]]
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[[Category: Eastwood, P]]
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[[Category: Engers, D.]]
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[[Category: Engers, D]]
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[[Category: Fenton, G.]]
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[[Category: Fenton, G]]
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[[Category: Gardyan, M.]]
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[[Category: Gardyan, M]]
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[[Category: Giardino, O.]]
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[[Category: Giardino, O]]
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[[Category: Guilloteau, J P.]]
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[[Category: Guilloteau, J P]]
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[[Category: Harrison, T.]]
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[[Category: Harrison, T]]
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[[Category: Houille, O.]]
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[[Category: Houille, O]]
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[[Category: Kwong, J.]]
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[[Category: Kwong, J]]
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[[Category: Levell, J.]]
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[[Category: Levell, J]]
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[[Category: Liang, G.]]
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[[Category: Liang, G]]
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[[Category: Lim, H K.]]
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[[Category: Lim, H K]]
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[[Category: Luo, Y.]]
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[[Category: Luo, Y]]
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[[Category: Maignan, S.]]
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[[Category: Maignan, S]]
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[[Category: Mathew, R.]]
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[[Category: Mathew, R]]
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[[Category: Mccarthy, C.]]
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[[Category: Mccarthy, C]]
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[[Category: Merriman, G.]]
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[[Category: Merriman, G]]
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[[Category: Morley, A.]]
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[[Category: Morley, A]]
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[[Category: Pauls, H.]]
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[[Category: Pauls, H]]
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[[Category: Pribish, J.]]
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[[Category: Pribish, J]]
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[[Category: Rebello, S.]]
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[[Category: Rebello, S]]
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[[Category: Romano, J.]]
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[[Category: Romano, J]]
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[[Category: Shen, L.]]
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[[Category: Shen, L]]
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[[Category: Sides, K.]]
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[[Category: Sides, K]]
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[[Category: Smith, K.]]
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[[Category: Smith, K]]
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[[Category: Tsay, J.]]
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[[Category: Tsay, J]]
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[[Category: Wang, J.]]
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[[Category: Wang, J]]
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[[Category: Watson, S.]]
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[[Category: Watson, S]]
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[[Category: Whiteley, B.]]
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[[Category: Whiteley, B]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 04:19, 25 December 2014

HUMAN BETA-II TRYPTASE IN COMPLEX WITH 4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE

2bm2, resolution 2.20Å

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