2bi0
From Proteopedia
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| - | [[Image:2bi0.gif|left|200px]] | + | [[Image:2bi0.gif|left|200px]] |
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| - | '''RV0216, A CONSERVED HYPOTHETICAL PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS THAT IS ESSENTIAL FOR BACTERIAL SURVIVAL DURING INFECTION, HAS A DOUBLE HOTDOGFOLD''' | + | {{Structure |
| + | |PDB= 2bi0 |SIZE=350|CAPTION= <scene name='initialview01'>2bi0</scene>, resolution 1.90Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+A'>AC1</scene> | ||
| + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''RV0216, A CONSERVED HYPOTHETICAL PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS THAT IS ESSENTIAL FOR BACTERIAL SURVIVAL DURING INFECTION, HAS A DOUBLE HOTDOGFOLD''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BI0 is a [ | + | 2BI0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI0 OCA]. |
==Reference== | ==Reference== | ||
| - | Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold., Castell A, Johansson P, Unge T, Jones TA, Backbro K, Protein Sci. 2005 Jul;14(7):1850-62. PMID:[http:// | + | Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold., Castell A, Johansson P, Unge T, Jones TA, Backbro K, Protein Sci. 2005 Jul;14(7):1850-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15987908 15987908] |
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: rv0216]] | [[Category: rv0216]] | ||
[[Category: spine]] | [[Category: spine]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:02:18 2008'' |
Revision as of 14:02, 20 March 2008
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| , resolution 1.90Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
RV0216, A CONSERVED HYPOTHETICAL PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS THAT IS ESSENTIAL FOR BACTERIAL SURVIVAL DURING INFECTION, HAS A DOUBLE HOTDOGFOLD
Overview
The Mycobacterium tuberculosis genome contains about 4000 genes, of which approximately a third code for proteins of unknown function or are classified as conserved hypothetical proteins. We have determined the three-dimensional structure of one of these, the rv0216 gene product, which has been shown to be essential for M. tuberculosis growth in vivo. The structure exhibits the greatest similarity to bacterial and eukaryotic hydratases that catalyse the R-specific hydration of 2-enoyl coenzyme A. However, only part of the catalytic machinery is conserved in Rv0216 and it showed no activity for the substrate crotonyl-CoA. The structure of Rv0216 allows us to assign new functional annotations to a family of seven other M. tuberculosis proteins, a number if which are essential for bacterial survival during infection and growth.
About this Structure
2BI0 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
Rv0216, a conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdog fold., Castell A, Johansson P, Unge T, Jones TA, Backbro K, Protein Sci. 2005 Jul;14(7):1850-62. PMID:15987908
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