3a6n
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a6n RCSB], [http://www.ebi.ac.uk/pdbsum/3a6n PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a6n RCSB], [http://www.ebi.ac.uk/pdbsum/3a6n PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/H31T_HUMAN H31T_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Histone|Histone]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Kagawa, W | + | [[Category: Kagawa, W]] |
| - | [[Category: Kimura, H | + | [[Category: Kimura, H]] |
| - | [[Category: Koichiro, K | + | [[Category: Koichiro, K]] |
| - | [[Category: Kurumizaka, H | + | [[Category: Kurumizaka, H]] |
| - | [[Category: Osakabe, A | + | [[Category: Osakabe, A]] |
| - | [[Category: Shiga, T | + | [[Category: Shiga, T]] |
| - | [[Category: Tachiwana, H | + | [[Category: Tachiwana, H]] |
[[Category: Antibiotic]] | [[Category: Antibiotic]] | ||
[[Category: Antimicrobial]] | [[Category: Antimicrobial]] | ||
Revision as of 04:31, 25 December 2014
The nucleosome containing a testis-specific histone variant, human H3T
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Categories: Homo sapiens | Kagawa, W | Kimura, H | Koichiro, K | Kurumizaka, H | Osakabe, A | Shiga, T | Tachiwana, H | Antibiotic | Antimicrobial | Chromosomal protein | Citrullination | Dna-binding | Dna-binding protein | Histone-fold | Isopeptide bond | Methylation | Nucleosome core | Nucleus | Phosphoprotein | Structural protein-dna complex
