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2jaw
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAW FirstGlance]. <br> | <table><tr><td colspan='2'>[[2jaw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAW FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BVP:(E)-5-(2-BROMOVINYL)-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BVP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BVP:(E)-5-(2-BROMOVINYL)-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BVP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mh9|1mh9]], [[1q91|1q91]], [[1q92|1q92]], [[1z4i|1z4i]], [[1z4j|1z4j]], [[1z4k|1z4k]], [[1z4l|1z4l]], [[1z4m|1z4m]], [[1z4p|1z4p]], [[1z4q|1z4q]], [[2jau|2jau]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mh9|1mh9]], [[1q91|1q91]], [[1q92|1q92]], [[1z4i|1z4i]], [[1z4j|1z4j]], [[1z4k|1z4k]], [[1z4l|1z4l]], [[1z4m|1z4m]], [[1z4p|1z4p]], [[1z4q|1z4q]], [[2jau|2jau]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jaw RCSB], [http://www.ebi.ac.uk/pdbsum/2jaw PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jaw RCSB], [http://www.ebi.ac.uk/pdbsum/2jaw PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bianchi, V | + | [[Category: Bianchi, V]] |
| - | [[Category: Nordlund, P | + | [[Category: Nordlund, P]] |
| - | [[Category: Ruzzenente, B | + | [[Category: Ruzzenente, B]] |
| - | [[Category: Wallden, K | + | [[Category: Wallden, K]] |
[[Category: Alfa beta fold]] | [[Category: Alfa beta fold]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 04:31, 25 December 2014
CRYSTAL STRUCTURE OF D41N VARIANT OF HUMAN MITOCHONDRIAL 5' (3')-DEOXYRIBONUCLEOTIDASE (MDN) IN COMPLEX WITH 5-BROMOVINYLDEOXYURIDINE 5'-MONOPHOSPHATE
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