4kre
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kre RCSB], [http://www.ebi.ac.uk/pdbsum/4kre PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kre OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kre RCSB], [http://www.ebi.ac.uk/pdbsum/4kre PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 04:43, 25 December 2014
Structure of Human Argonaute-1 bound to endogenous Sf9 RNA
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