2i1p
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br> | <table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LRP2_RAT LRP2_RAT]] Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.<ref>PMID:7544804</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Bade-Noskova, V | + | [[Category: Bade-Noskova, V]] |
| - | [[Category: Dancea, F | + | [[Category: Dancea, F]] |
| - | [[Category: Kerjaschki, D | + | [[Category: Kerjaschki, D]] |
| - | [[Category: Luecke, C | + | [[Category: Luecke, C]] |
| - | [[Category: Rueterjans, H | + | [[Category: Rueterjans, H]] |
| - | [[Category: Shi, M | + | [[Category: Shi, M]] |
| - | [[Category: Wolf, C A | + | [[Category: Wolf, C A]] |
[[Category: Calcium cage]] | [[Category: Calcium cage]] | ||
[[Category: Cysteine-rich repeat]] | [[Category: Cysteine-rich repeat]] | ||
Revision as of 04:46, 25 December 2014
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin
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