2blf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2blf.gif|left|200px]]<br /><applet load="2blf" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2blf.gif|left|200px]]
-
caption="2blf, resolution 1.80&Aring;" />
+
 
-
'''SULFITE DEHYDROGENASE FROM STARKEYA NOVELLA'''<br />
+
{{Structure
 +
|PDB= 2blf |SIZE=350|CAPTION= <scene name='initialview01'>2blf</scene>, resolution 1.80&Aring;
 +
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>
 +
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MSS:(MOLYBDOPTERIN-S,S)-OXO-MOLYBDENUM'>MSS</scene> and <scene name='pdbligand=HEC:HEME C'>HEC</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''SULFITE DEHYDROGENASE FROM STARKEYA NOVELLA'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
2BLF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Starkeya_novella Starkeya novella] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MSS:'>MSS</scene> and <scene name='pdbligand=HEC:'>HEC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLF OCA].
+
2BLF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Starkeya_novella Starkeya novella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLF OCA].
==Reference==
==Reference==
-
Molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit., Kappler U, Bailey S, J Biol Chem. 2005 Jul 1;280(26):24999-5007. Epub 2005 Apr 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15863498 15863498]
+
Molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit., Kappler U, Bailey S, J Biol Chem. 2005 Jul 1;280(26):24999-5007. Epub 2005 Apr 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15863498 15863498]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Starkeya novella]]
[[Category: Starkeya novella]]
Line 25: Line 34:
[[Category: sulfite oxidase]]
[[Category: sulfite oxidase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:39:05 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:03:28 2008''

Revision as of 14:03, 20 March 2008

Image:2blf.gif


PDB ID 2blf

Drag the structure with the mouse to rotate
, resolution 1.80Å
Sites:
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



SULFITE DEHYDROGENASE FROM STARKEYA NOVELLA


Overview

Sulfite-oxidizing molybdoenzymes convert the highly reactive and therefore toxic sulfite to sulfate and have been identified in insects, animals, plants, and bacteria. Although the well studied enzymes from higher animals serve to detoxify sulfite that arises from the catabolism of sulfur-containing amino acids, the bacterial enzymes have a central role in converting sulfite formed during dissimilatory oxidation of reduced sulfur compounds. Here we describe the structure of the Starkeya novella sulfite dehydrogenase, a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit, that reveals the molecular mechanism of intramolecular electron transfer in sulfite-oxidizing enzymes. The close approach of the two redox centers in the protein complex (Mo-Fe distance 16.6 A) allows for rapid electron transfer via tunnelling or aided by the protein environment. The high resolution structure of the complex has allowed the identification of potential through-bond pathways for electron transfer including a direct link via Arg-55A and/or an aromatic-mediated pathway. A potential site of electron transfer to an external acceptor cytochrome c was also identified on the SorB subunit on the opposite side to the interaction with the catalytic SorA subunit.

About this Structure

2BLF is a Protein complex structure of sequences from Starkeya novella. Full crystallographic information is available from OCA.

Reference

Molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit., Kappler U, Bailey S, J Biol Chem. 2005 Jul 1;280(26):24999-5007. Epub 2005 Apr 29. PMID:15863498

Page seeded by OCA on Thu Mar 20 16:03:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2blf"
Personal tools