3t5q
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3t5q]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Mopeia_lassa_reassortant_29 Mopeia lassa reassortant 29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T5Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[3t5q]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Mopeia_lassa_reassortant_29 Mopeia lassa reassortant 29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T5Q FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t5n|3t5n]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t5n|3t5n]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300180 Mopeia Lassa reassortant 29])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300180 Mopeia Lassa reassortant 29])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t5q RCSB], [http://www.ebi.ac.uk/pdbsum/3t5q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t5q RCSB], [http://www.ebi.ac.uk/pdbsum/3t5q PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q5S585_9VIRU Q5S585_9VIRU]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses (By similarity).[PIRNR:PIRNR004029] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.,Hastie KM, Liu T, Li S, King LB, Ngo N, Zandonatti MA, Woods VL Jr, de la Torre JC, Saphire EO Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19365-70. Epub 2011 Nov 14. PMID:22084115<ref>PMID:22084115</ref> | Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.,Hastie KM, Liu T, Li S, King LB, Ngo N, Zandonatti MA, Woods VL Jr, de la Torre JC, Saphire EO Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19365-70. Epub 2011 Nov 14. PMID:22084115<ref>PMID:22084115</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Mopeia lassa reassortant 29]] | [[Category: Mopeia lassa reassortant 29]] | ||
| - | [[Category: Hastie, K M | + | [[Category: Hastie, K M]] |
| - | [[Category: King, L B | + | [[Category: King, L B]] |
| - | [[Category: Liu, T | + | [[Category: Liu, T]] |
| - | [[Category: Ngo, N | + | [[Category: Ngo, N]] |
| - | [[Category: Saphire, E O | + | [[Category: Saphire, E O]] |
| - | [[Category: Torre, J C.de la | + | [[Category: Torre, J C.de la]] |
| - | [[Category: Woods, V L | + | [[Category: Woods, V L]] |
| - | [[Category: Zandonatti, M A | + | [[Category: Zandonatti, M A]] |
[[Category: Single stranded rna]] | [[Category: Single stranded rna]] | ||
[[Category: Ssrna]] | [[Category: Ssrna]] | ||
[[Category: Viral protein-rna complex]] | [[Category: Viral protein-rna complex]] | ||
Revision as of 04:55, 25 December 2014
3A structure of Lassa virus nucleoprotein in complex with ssRNA
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