2ror
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROR FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ROR FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VAV1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [http://www.ebi.ac.uk/pdbsum/2ror PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. [[http://www.uniprot.org/uniprot/LCP2_HUMAN LCP2_HUMAN]] Involved in T-cell antigen receptor mediated signaling. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Kasai, T | + | [[Category: Kasai, T]] |
| - | [[Category: Kigawa, T | + | [[Category: Kigawa, T]] |
| - | [[Category: Koshiba, S | + | [[Category: Koshiba, S]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Tanaka, M | + | [[Category: Tanaka, M]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
[[Category: Guanine-nucleotide releasing factor]] | [[Category: Guanine-nucleotide releasing factor]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
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[[Category: Protein-peptide complex]] | [[Category: Protein-peptide complex]] | ||
[[Category: Proto-oncogene]] | [[Category: Proto-oncogene]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Sh2 domain]] | [[Category: Sh2 domain]] | ||
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[[Category: Signal transduction]] | [[Category: Signal transduction]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 04:55, 25 December 2014
Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76
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Categories: Homo sapiens | Kasai, T | Kigawa, T | Koshiba, S | Structural genomic | Tanaka, M | Yokoyama, S | Guanine-nucleotide releasing factor | Metal-binding | National project on protein structural and functional analyse | Nppsfa | Phorbol-ester binding | Phosphoprotein | Phosphorylated peptide recognition | Phosphotyrosine binding domain | Protein-peptide complex | Proto-oncogene | Rsgi | Sh2 domain | Sh3 domain | Signal transduction | Signaling protein | Zinc-finger
