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1u4f
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1u4f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U4F FirstGlance]. <br> | <table><tr><td colspan='2'>[[1u4f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U4F FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p7b|1p7b]], [[1n9p|1n9p]], [[1u4e|1u4e]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p7b|1p7b]], [[1n9p|1n9p]], [[1u4e|1u4e]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnj2, IRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnj2, IRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u4f RCSB], [http://www.ebi.ac.uk/pdbsum/1u4f PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u4f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u4f RCSB], [http://www.ebi.ac.uk/pdbsum/1u4f PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IRK2_MOUSE IRK2_MOUSE]] Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Arrabit, C | + | [[Category: Arrabit, C]] |
| - | [[Category: Choe, S | + | [[Category: Choe, S]] |
| - | [[Category: Kwiatkowski, W | + | [[Category: Kwiatkowski, W]] |
| - | [[Category: Pegan, S | + | [[Category: Pegan, S]] |
| - | [[Category: Slesinger, P A | + | [[Category: Slesinger, P A]] |
| - | [[Category: Zhou, W | + | [[Category: Zhou, W]] |
[[Category: Allergen]] | [[Category: Allergen]] | ||
[[Category: Cytoplasmic domain]] | [[Category: Cytoplasmic domain]] | ||
Revision as of 04:58, 25 December 2014
Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel
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