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2p8u

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2p8u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8U FirstGlance]. <br>
<table><tr><td colspan='2'>[[2p8u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8U FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMGCS1, HMGCS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMGCS1, HMGCS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_synthase Hydroxymethylglutaryl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.10 2.3.3.10] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8u RCSB], [http://www.ebi.ac.uk/pdbsum/2p8u PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8u RCSB], [http://www.ebi.ac.uk/pdbsum/2p8u PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HMCS1_HUMAN HMCS1_HUMAN]] This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hydroxymethylglutaryl-CoA synthase]]
[[Category: Hydroxymethylglutaryl-CoA synthase]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi, G]]
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[[Category: Burgess, N.]]
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[[Category: Burgess, N]]
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[[Category: Debreczeni, J.]]
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[[Category: Debreczeni, J]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Gorrec, F.]]
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[[Category: Gorrec, F]]
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[[Category: Niesen, F H.]]
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[[Category: Niesen, F H]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann, U]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike, A C.W]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Salah, E.]]
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[[Category: Salah, E]]
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[[Category: Shafqat, N.]]
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[[Category: Shafqat, N]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom, M]]
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[[Category: Turnbull, A.]]
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[[Category: Turnbull, A]]
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[[Category: Umeano, C.]]
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[[Category: Umeano, C]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Hydromethylglutaryl coa]]
[[Category: Hydromethylglutaryl coa]]
[[Category: Mevalonate pathway]]
[[Category: Mevalonate pathway]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 05:08, 25 December 2014

Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I

2p8u, resolution 2.00Å

Drag the structure with the mouse to rotate

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