3vyy
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vyy RCSB], [http://www.ebi.ac.uk/pdbsum/3vyy PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vyy RCSB], [http://www.ebi.ac.uk/pdbsum/3vyy PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DHX9_HUMAN DHX9_HUMAN]] Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression.<ref>PMID:19029303</ref> <ref>PMID:19229320</ref> <ref>PMID:22190748</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 05:10, 25 December 2014
Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9)
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