3s32
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3s32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S32 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3s32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S32 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s32 RCSB], [http://www.ebi.ac.uk/pdbsum/3s32 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s32 RCSB], [http://www.ebi.ac.uk/pdbsum/3s32 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN]] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.,Sarvan S, Avdic V, Tremblay V, Chaturvedi CP, Zhang P, Lanouette S, Blais A, Brunzelle JS, Brand M, Couture JF Nat Struct Mol Biol. 2011 Jun 5;18(7):857-9. doi: 10.1038/nsmb.2093. PMID:21642971<ref>PMID:21642971</ref> | Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.,Sarvan S, Avdic V, Tremblay V, Chaturvedi CP, Zhang P, Lanouette S, Blais A, Brunzelle JS, Brand M, Couture JF Nat Struct Mol Biol. 2011 Jun 5;18(7):857-9. doi: 10.1038/nsmb.2093. PMID:21642971<ref>PMID:21642971</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Avdic, V | + | [[Category: Avdic, V]] |
| - | [[Category: Blais, A | + | [[Category: Blais, A]] |
| - | [[Category: Brand, M | + | [[Category: Brand, M]] |
| - | [[Category: Brunzelle, J S | + | [[Category: Brunzelle, J S]] |
| - | [[Category: Chaturvedi, C P | + | [[Category: Chaturvedi, C P]] |
| - | [[Category: Couture, J F | + | [[Category: Couture, J F]] |
| - | [[Category: Lanouette, S | + | [[Category: Lanouette, S]] |
| - | [[Category: Sarvan, S | + | [[Category: Sarvan, S]] |
| - | [[Category: Tremblay, V | + | [[Category: Tremblay, V]] |
| - | [[Category: Zhang, P | + | [[Category: Zhang, P]] |
[[Category: C4-zinc finger]] | [[Category: C4-zinc finger]] | ||
[[Category: Chromatin]] | [[Category: Chromatin]] | ||
Revision as of 05:23, 25 December 2014
Crystal structure of Ash2L N-terminal domain
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Categories: Homo sapiens | Avdic, V | Blais, A | Brand, M | Brunzelle, J S | Chaturvedi, C P | Couture, J F | Lanouette, S | Sarvan, S | Tremblay, V | Zhang, P | C4-zinc finger | Chromatin | Helix-wing-helix | Histone | Myeloid lymphoma leukemia protein | Nucleus | Transcription | Trithorax | Trithorax group protein
