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2ktd

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ktd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ktd RCSB], [http://www.ebi.ac.uk/pdbsum/2ktd PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ktd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ktd RCSB], [http://www.ebi.ac.uk/pdbsum/2ktd PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PTGDS_MOUSE PTGDS_MOUSE]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:8922532</ref> <ref>PMID:9892701</ref> <ref>PMID:10781097</ref> <ref>PMID:11751991</ref> <ref>PMID:12077186</ref> <ref>PMID:17715133</ref> <ref>PMID:19546224</ref> <ref>PMID:19833210</ref>
==See Also==
==See Also==
*[[Prostaglandin D synthase|Prostaglandin D synthase]]
*[[Prostaglandin D synthase|Prostaglandin D synthase]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Revision as of 05:29, 25 December 2014

Solution structure of mouse lipocalin-type prostaglandin D synthase / substrate analog (U-46619) complex

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