2qme
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qme RCSB], [http://www.ebi.ac.uk/pdbsum/2qme PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qme RCSB], [http://www.ebi.ac.uk/pdbsum/2qme PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref> [[http://www.uniprot.org/uniprot/PAK1_HUMAN PAK1_HUMAN]] Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2.<ref>PMID:8805275</ref> <ref>PMID:9395435</ref> <ref>PMID:9032240</ref> <ref>PMID:9528787</ref> <ref>PMID:10551809</ref> <ref>PMID:11733498</ref> <ref>PMID:12624090</ref> <ref>PMID:12876277</ref> <ref>PMID:14585966</ref> <ref>PMID:15611088</ref> <ref>PMID:15831477</ref> <ref>PMID:16278681</ref> <ref>PMID:17726028</ref> <ref>PMID:17989089</ref> <ref>PMID:22669945</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | *[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bunkoczi, G | + | [[Category: Bunkoczi, G]] |
| - | [[Category: Burgess-Brown, N | + | [[Category: Burgess-Brown, N]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Doyle, D | + | [[Category: Doyle, D]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Elkins, J M | + | [[Category: Elkins, J M]] |
| - | [[Category: Knapp, S | + | [[Category: Knapp, S]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Sundstrom, M | + | [[Category: Sundstrom, M]] |
| - | [[Category: Ugochukwu, E | + | [[Category: Ugochukwu, E]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
| - | [[Category: Yang, X | + | [[Category: Yang, X]] |
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
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[[Category: Signaling protein-transferase complex]] | [[Category: Signaling protein-transferase complex]] | ||
[[Category: Small gtp binding protein]] | [[Category: Small gtp binding protein]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 05:31, 25 December 2014
Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)
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Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Arrowsmith, C H | Bunkoczi, G | Burgess-Brown, N | Delft, F von | Doyle, D | Edwards, A | Elkins, J M | Knapp, S | Structural genomic | Sundstrom, M | Ugochukwu, E | Weigelt, J | Yang, X | Allosteric enzyme | Apoptosis | Atp-binding | Cell junction | Cell projection | Crib | Gtp-binding | Gtpase rac3 | Kinase | Lipoprotein | Membrane | Methylation | Nucleotide-binding | P21 rac | Phosphorylation | Prenylation | Ras-related c3 botulinum toxin substrate 3 | Serine/threonine-protein kinase | Sgc | Signaling protein | Signaling protein-transferase complex | Small gtp binding protein | Transferase
