4oi8
From Proteopedia
(Difference between revisions)
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<StructureSection load='4oi8' size='340' side='right' caption='[[4oi8]], [[Resolution|resolution]] 3.10Å' scene=''> | <StructureSection load='4oi8' size='340' side='right' caption='[[4oi8]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4oi8]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3s59 3s59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OI8 OCA]. <br> | + | <table><tr><td colspan='2'>[[4oi8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3s59 3s59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OI8 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oi7|4oi7]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oi7|4oi7]]</td></tr> |
| - | <tr><td class="sblockLbl"><b> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGER, RAGE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oi8 RCSB], [http://www.ebi.ac.uk/pdbsum/4oi8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oi8 RCSB], [http://www.ebi.ac.uk/pdbsum/4oi8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN]] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.,Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep , 30. PMID:24081950<ref>PMID:24081950</ref> | RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.,Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep , 30. PMID:24081950<ref>PMID:24081950</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Jiang, J | + | [[Category: Human]] |
| - | [[Category: Jin, T | + | [[Category: Jiang, J]] |
| - | [[Category: Xiao, T | + | [[Category: Jin, T]] |
| + | [[Category: Xiao, T]] | ||
[[Category: Dna binding]] | [[Category: Dna binding]] | ||
[[Category: Ig fold]] | [[Category: Ig fold]] | ||
[[Category: Signaling protein-dna complex]] | [[Category: Signaling protein-dna complex]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 05:47, 25 December 2014
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
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