1rr9
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1rr9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RR9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1rr9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RR9 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rre|1rre]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rre|1rre]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LON, CAPR, DEG, MUC, LOPA, B0439, C0555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LON, CAPR, DEG, MUC, LOPA, B0439, C0555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1rr9 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1rr9 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LON_ECOLI LON_ECOLI]] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.<ref>PMID:12135363</ref> <ref>PMID:16584195</ref> <ref>PMID:19721064</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 35: | ||
[[Category: Endopeptidase La]] | [[Category: Endopeptidase La]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Botos, I | + | [[Category: Botos, I]] |
| - | [[Category: Cherry, S | + | [[Category: Cherry, S]] |
| - | [[Category: Dauter, Z | + | [[Category: Dauter, Z]] |
| - | [[Category: Gustchina, A | + | [[Category: Gustchina, A]] |
| - | [[Category: Khalatova, A G | + | [[Category: Khalatova, A G]] |
| - | [[Category: Maurizi, M R | + | [[Category: Maurizi, M R]] |
| - | [[Category: Melnikov, E E | + | [[Category: Melnikov, E E]] |
| - | [[Category: Rotanova, T V | + | [[Category: Rotanova, T V]] |
| - | [[Category: Tropea, J E | + | [[Category: Tropea, J E]] |
| - | [[Category: Wlodawer, A | + | [[Category: Wlodawer, A]] |
[[Category: Atp-dependent protease]] | [[Category: Atp-dependent protease]] | ||
[[Category: Catalytic dyad ser-ly]] | [[Category: Catalytic dyad ser-ly]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 05:48, 25 December 2014
Catalytic domain of E.coli Lon protease
| |||||||||||
