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3met
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3met FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3met OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3met RCSB], [http://www.ebi.ac.uk/pdbsum/3met PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3met FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3met OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3met RCSB], [http://www.ebi.ac.uk/pdbsum/3met PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SGF29_HUMAN SGF29_HUMAN]] Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.<ref>PMID:19103755</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 05:48, 25 December 2014
Crystal structure of SGF29 in complex with H3K4me2
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