1k93
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1k93]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Calmodulin'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_8 10.2210/rcsb_pdb/mom_2003_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K93 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1k93]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2003 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Calmodulin'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2003_8 10.2210/rcsb_pdb/mom_2003_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K93 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k8t|1k8t]], [[1k9o|1k9o]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k8t|1k8t]], [[1k9o|1k9o]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k93 RCSB], [http://www.ebi.ac.uk/pdbsum/1k93 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k93 RCSB], [http://www.ebi.ac.uk/pdbsum/1k93 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CYAA_BACAN CYAA_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Bard, J | + | [[Category: Bard, J]] |
| - | [[Category: Bohm, A | + | [[Category: Bohm, A]] |
| - | [[Category: Drum, C L | + | [[Category: Drum, C L]] |
| - | [[Category: Grabarek, Z | + | [[Category: Grabarek, Z]] |
| - | [[Category: Lu, D | + | [[Category: Lu, D]] |
| - | [[Category: Shen, Y Q | + | [[Category: Shen, Y Q]] |
| - | [[Category: Soelaiman, S | + | [[Category: Soelaiman, S]] |
| - | [[Category: Tang, W J | + | [[Category: Tang, W J]] |
| - | [[Category: Yan, S Z | + | [[Category: Yan, S Z]] |
[[Category: Adenylyl cyclase]] | [[Category: Adenylyl cyclase]] | ||
[[Category: Anthrax]] | [[Category: Anthrax]] | ||
| - | [[Category: Calmodulin]] | ||
[[Category: Edema factor]] | [[Category: Edema factor]] | ||
[[Category: Lyase-metal binding protein complex]] | [[Category: Lyase-metal binding protein complex]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 05:57, 25 December 2014
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin
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Categories: Adenylate cyclase | Bacillus anthracis | Calmodulin | Homo sapiens | RCSB PDB Molecule of the Month | Bard, J | Bohm, A | Drum, C L | Grabarek, Z | Lu, D | Shen, Y Q | Soelaiman, S | Tang, W J | Yan, S Z | Adenylyl cyclase | Anthrax | Edema factor | Lyase-metal binding protein complex | Toxin
