2bv6
From Proteopedia
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| - | [[Image:2bv6.gif|left|200px]] | + | [[Image:2bv6.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS''' | + | {{Structure |
| + | |PDB= 2bv6 |SIZE=350|CAPTION= <scene name='initialview01'>2bv6</scene>, resolution 2.80Å | ||
| + | |SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene> | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BV6 is a [ | + | 2BV6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BV6 OCA]. |
==Reference== | ==Reference== | ||
| - | An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus., Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C, Nat Chem Biol. 2006 Nov;2(11):591-5. Epub 2006 Sep 17. PMID:[http:// | + | An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus., Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C, Nat Chem Biol. 2006 Nov;2(11):591-5. Epub 2006 Sep 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16980961 16980961] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
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[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: multidrug resistance regulator]] | [[Category: multidrug resistance regulator]] | ||
| - | [[Category: transcriptional | + | [[Category: transcriptional factor]] |
[[Category: virulence determinant]] | [[Category: virulence determinant]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:07:10 2008'' |
Revision as of 14:07, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Sites: | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS
Overview
Staphylococcus aureus is a human pathogen responsible for most wound and hospital-acquired infections. The protein MgrA is both an important virulence determinant during infection and a regulator of antibiotic resistance in S. aureus. The crystal structure of the MgrA homodimer, solved at 2.86 A, indicates the presence of a unique cysteine residue located at the interface of the protein dimer. We discovered that this cysteine residue can be oxidized by various reactive oxygen species, such as hydrogen peroxide and organic hydroperoxide. Cysteine oxidation leads to dissociation of MgrA from DNA and initiation of signaling pathways that turn on antibiotic resistance in S. aureus. The oxidation-sensing mechanism is typically used by bacteria to counter challenges of reactive oxygen and nitrogen species. Our study reveals that in S. aureus, MgrA adopts a similar mechanism but uses it to globally regulate different defensive pathways.
About this Structure
2BV6 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus., Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C, Nat Chem Biol. 2006 Nov;2(11):591-5. Epub 2006 Sep 17. PMID:16980961
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