3u21

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3u21.png|left|200px]]
+
==Crystal structure of a Fragment of Nuclear factor related to kappa-B-binding protein (residues 370-495) (NFRKB) from Homo sapiens at 2.18 A resolution==
 +
<StructureSection load='3u21' size='340' side='right' caption='[[3u21]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3u21]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U21 FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 +
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 +
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BC063280, INO80G, NFRKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u21 RCSB], [http://www.ebi.ac.uk/pdbsum/3u21 PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/NFRKB_HUMAN NFRKB_HUMAN]] Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.<ref>PMID:18922472</ref> Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.<ref>PMID:18922472</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The human nuclear factor related to kappa-B-binding protein (NFRKB) is a 1299-residue protein that is a component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. Although full length NFRKB is predicted to be around 65% disordered, comparative sequence analysis identified several potentially structured sections in the N-terminal region of the protein. These regions were targeted for crystallographic studies, and the structure of one of these regions spanning residues 370-495 was determined using the JCSG high-throughput structure determination pipeline. The structure reveals a novel, mostly helical domain reminiscent of the winged-helix fold typically involved in DNA binding. However, further analysis shows that this domain does not bind DNA, suggesting it may belong to a small group of winged-helix domains involved in protein-protein interactions.
-
{{STRUCTURE_3u21| PDB=3u21 | SCENE= }}
+
Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein.,Kumar A, Mocklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA PLoS One. 2012;7(9):e43761. Epub 2012 Sep 11. PMID:22984442<ref>PMID:22984442</ref>
-
===Crystal structure of a Fragment of Nuclear factor related to kappa-B-binding protein (residues 370-495) (NFRKB) from Homo sapiens at 2.18 A resolution===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_22984442}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[3u21]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U21 OCA].
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Biology, Partnership for Stem Cell.]]
+
[[Category: Biology, Partnership for Stem Cell]]
-
[[Category: JCSG, Joint Center for Structural Genomics.]]
+
[[Category: Structural genomic]]
-
[[Category: STEMCELL, Partnership for Stem Cell Biology.]]
+
[[Category: STEMCELL, Partnership for Stem Cell Biology]]
[[Category: Dna binding]]
[[Category: Dna binding]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Dna/rna-binding 3-helical bundle]]
[[Category: Dna/rna-binding 3-helical bundle]]
[[Category: Jcsg]]
[[Category: Jcsg]]
-
[[Category: Joint center for structural genomic]]
 
[[Category: Partnership for stem cell biology]]
[[Category: Partnership for stem cell biology]]
-
[[Category: Protein structure initiative]]
+
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
-
[[Category: Structural genomic]]
 
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Winged-hth domain]]
[[Category: Winged-hth domain]]

Revision as of 06:03, 25 December 2014

Crystal structure of a Fragment of Nuclear factor related to kappa-B-binding protein (residues 370-495) (NFRKB) from Homo sapiens at 2.18 A resolution

3u21, resolution 2.18Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3u21"
Personal tools