4cbw
From Proteopedia
(Difference between revisions)
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<StructureSection load='4cbw' size='340' side='right' caption='[[4cbw]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4cbw' size='340' side='right' caption='[[4cbw]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Plabe Plabe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBW OCA]. <br> | + | <table><tr><td colspan='2'>[[4cbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Plabe Plabe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CBW FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbu|4cbu]], [[4cbx|4cbx]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbu|4cbu]], [[4cbx|4cbx]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cbw RCSB], [http://www.ebi.ac.uk/pdbsum/4cbw PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/ACT1_PLABA ACT1_PLABA]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/GELS_MOUSE GELS_MOUSE]] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural differences explain diverse functions of Plasmodium actins.,Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Siden-Kiamos I, Sachse C, Kursula I PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091., eCollection 2014 Apr. PMID:24743229<ref>PMID:24743229</ref> | Structural differences explain diverse functions of Plasmodium actins.,Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Siden-Kiamos I, Sachse C, Kursula I PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091., eCollection 2014 Apr. PMID:24743229<ref>PMID:24743229</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Plabe]] | [[Category: Plabe]] | ||
| - | [[Category: Andreadaki, M | + | [[Category: Andreadaki, M]] |
| - | [[Category: Bhargav, S P | + | [[Category: Bhargav, S P]] |
| - | [[Category: Desfosses, A | + | [[Category: Desfosses, A]] |
| - | [[Category: Frischknecht, F | + | [[Category: Frischknecht, F]] |
| - | [[Category: Ignatev, A | + | [[Category: Ignatev, A]] |
| - | [[Category: Kumpula, E P | + | [[Category: Kumpula, E P]] |
| - | [[Category: Kursula, I | + | [[Category: Kursula, I]] |
| - | [[Category: Lepper, S | + | [[Category: Lepper, S]] |
| - | [[Category: Martinez, S Munico | + | [[Category: Martinez, S Munico]] |
| - | [[Category: Sachse, C | + | [[Category: Sachse, C]] |
| - | [[Category: Siden-Kiamos, I | + | [[Category: Siden-Kiamos, I]] |
| - | [[Category: Vahokoski, J | + | [[Category: Vahokoski, J]] |
[[Category: Malaria]] | [[Category: Malaria]] | ||
[[Category: Motility]] | [[Category: Motility]] | ||
[[Category: Motor protein]] | [[Category: Motor protein]] | ||
[[Category: Parasite]] | [[Category: Parasite]] | ||
Revision as of 06:11, 25 December 2014
Crystal structure of Plasmodium berghei actin I with D-loop from muscle actin
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