2l9h
From Proteopedia
(Difference between revisions)
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<StructureSection load='2l9h' size='340' side='right' caption='[[2l9h]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | <StructureSection load='2l9h' size='340' side='right' caption='[[2l9h]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l9h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9H OCA]. <br> | + | <table><tr><td colspan='2'>[[2l9h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L9H FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u4l|1u4l]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u4l|1u4l]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL5, D17S136E, SCYA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL5, D17S136E, SCYA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l9h RCSB], [http://www.ebi.ac.uk/pdbsum/2l9h PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN]] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data.,Wang X, Watson C, Sharp JS, Handel TM, Prestegard JH Structure. 2011 Aug 10;19(8):1138-48. PMID:21827949<ref>PMID:21827949</ref> | Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data.,Wang X, Watson C, Sharp JS, Handel TM, Prestegard JH Structure. 2011 Aug 10;19(8):1138-48. PMID:21827949<ref>PMID:21827949</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Handel, T M | + | [[Category: Handel, T M]] |
| - | [[Category: Prestegard, J H | + | [[Category: Prestegard, J H]] |
| - | [[Category: Sharp, J S | + | [[Category: Sharp, J S]] |
| - | [[Category: Wang, X | + | [[Category: Wang, X]] |
| - | [[Category: Watson, C M | + | [[Category: Watson, C M]] |
[[Category: Chemokine]] | [[Category: Chemokine]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Oligomer]] | [[Category: Oligomer]] | ||
Revision as of 06:12, 25 December 2014
Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data
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