2cjq
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2cjq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2cjq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJQ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ajj|2ajj]], [[2ajm|2ajm]], [[2ajn|2ajn]], [[2ajo|2ajo]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ajj|2ajj]], [[2ajm|2ajm]], [[2ajn|2ajn]], [[2ajo|2ajo]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjq RCSB], [http://www.ebi.ac.uk/pdbsum/2cjq PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjq RCSB], [http://www.ebi.ac.uk/pdbsum/2cjq PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC]] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity). P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity). Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Bovine viral diarrhea virus 1]] | [[Category: Bovine viral diarrhea virus 1]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
| - | [[Category: Becher, P | + | [[Category: Becher, P]] |
| - | [[Category: Choi, K H | + | [[Category: Choi, K H]] |
| - | [[Category: Gallei, A | + | [[Category: Gallei, A]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Bovine viral diarrhea virus]] | [[Category: Bovine viral diarrhea virus]] | ||
Revision as of 06:20, 25 December 2014
BOVINE VIRAL DIARRHEA VIRUS CP7-R12 RNA-DEPENDENT RNA POLYMERASE
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Categories: Bovine viral diarrhea virus 1 | RNA-directed RNA polymerase | Becher, P | Choi, K H | Gallei, A | Rossmann, M G | Atp-binding | Bovine viral diarrhea virus | Bvdv | Glycoprotein | Helicase | Hydrolase | Membrane | Nucleotide-binding | Nucleotidyltransferase | Polyprotein | Protease | Rna-dependent rna polymerase | Rna-directed rna polymerase | Serine protease | Thiol protease | Transferase | Transmembrane | Viral polymerase
