1x2r
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1x2r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X2R FirstGlance]. <br> | <table><tr><td colspan='2'>[[1x2r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X2R FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x2j|1x2j]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x2j|1x2j]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x2r RCSB], [http://www.ebi.ac.uk/pdbsum/1x2r PDBsum], [http://www.topsan.org/Proteins/RSGI/1x2r TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x2r RCSB], [http://www.ebi.ac.uk/pdbsum/1x2r PDBsum], [http://www.topsan.org/Proteins/RSGI/1x2r TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> [[http://www.uniprot.org/uniprot/NF2L2_MOUSE NF2L2_MOUSE]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:9887101</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Kang, M I | + | [[Category: Kang, M I]] |
| - | [[Category: Kobayashi, A | + | [[Category: Kobayashi, A]] |
| - | [[Category: Nakamura, Y | + | [[Category: Nakamura, Y]] |
| - | [[Category: Ohta, T | + | [[Category: Ohta, T]] |
| - | [[Category: Ohtsuji, M | + | [[Category: Ohtsuji, M]] |
| - | [[Category: Padmanabhan, B | + | [[Category: Padmanabhan, B]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Scharlock, M | + | [[Category: Scharlock, M]] |
| - | [[Category: Tong, K I | + | [[Category: Tong, K I]] |
| - | [[Category: Yamamoto, M | + | [[Category: Yamamoto, M]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
[[Category: Beta propeller]] | [[Category: Beta propeller]] | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 06:22, 25 December 2014
Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
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