4w8v
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w8v RCSB], [http://www.ebi.ac.uk/pdbsum/4w8v PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w8v RCSB], [http://www.ebi.ac.uk/pdbsum/4w8v PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CMR6_PYRFU CMR6_PYRFU]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA, generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. It is not known which subunit has endoribonuclease activity. Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of invading RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not necessary for cleavage.<ref>PMID:19945378</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Baumgaertner, M | + | [[Category: Baumgaertner, M]] |
| - | [[Category: Benda, C | + | [[Category: Benda, C]] |
| - | [[Category: Conti, E | + | [[Category: Conti, E]] |
| - | [[Category: Ebert, J | + | [[Category: Ebert, J]] |
[[Category: Cmr complex]] | [[Category: Cmr complex]] | ||
[[Category: Rna binding protein]] | [[Category: Rna binding protein]] | ||
Revision as of 06:25, 25 December 2014
Crystal structure of Cmr6 from Pyrococcus furiosus
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