2kxa
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxa RCSB], [http://www.ebi.ac.uk/pdbsum/2kxa PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxa RCSB], [http://www.ebi.ac.uk/pdbsum/2kxa PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9YTC2_9INFA Q9YTC2_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00046902] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
| - | [[Category: Bax, A | + | [[Category: Bax, A]] |
| - | [[Category: Lorieau, J L | + | [[Category: Lorieau, J L]] |
| - | [[Category: Louis, J M | + | [[Category: Louis, J M]] |
[[Category: Fusion peptide]] | [[Category: Fusion peptide]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Influenza]] | [[Category: Influenza]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 06:32, 25 December 2014
The hemagglutinin fusion peptide (H1 subtype) at pH 7.4
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