1jas
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jas]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JAS FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jas]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JAS FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jas RCSB], [http://www.ebi.ac.uk/pdbsum/1jas PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jas OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jas RCSB], [http://www.ebi.ac.uk/pdbsum/1jas PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UBE2B_HUMAN UBE2B_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.<ref>PMID:1717990</ref> <ref>PMID:16337599</ref> <ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:20061386</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Ubiquitin conjugating enzyme|Ubiquitin conjugating enzyme]] | *[[Ubiquitin conjugating enzyme|Ubiquitin conjugating enzyme]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ubiquitin--protein ligase]] | [[Category: Ubiquitin--protein ligase]] | ||
| - | [[Category: Guentert, P | + | [[Category: Guentert, P]] |
| - | [[Category: Klaus, W | + | [[Category: Klaus, W]] |
| - | [[Category: Miura, T | + | [[Category: Miura, T]] |
| - | [[Category: Ross, A | + | [[Category: Ross, A]] |
| - | [[Category: Senn, H | + | [[Category: Senn, H]] |
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Ubiquitin conjugating enzyme]] | [[Category: Ubiquitin conjugating enzyme]] | ||
[[Category: Ubiquitin conjugation]] | [[Category: Ubiquitin conjugation]] | ||
Revision as of 06:34, 25 December 2014
HsUbc2b
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