1ymt
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ymt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YMT FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ymt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YMT FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DR9:1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL+PHOSPHATIDYL+GLYCEROL'>DR9</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DR9:1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL+PHOSPHATIDYL+GLYCEROL'>DR9</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr5a1, Ftzf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr5a1, Ftzf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ymt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ymt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ymt RCSB], [http://www.ebi.ac.uk/pdbsum/1ymt PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ymt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ymt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ymt RCSB], [http://www.ebi.ac.uk/pdbsum/1ymt PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/STF1_MOUSE STF1_MOUSE]] Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.<ref>PMID:17210646</ref> <ref>PMID:18988706</ref> [[http://www.uniprot.org/uniprot/SHP_MOUSE SHP_MOUSE]] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.<ref>PMID:8650544</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Bynum, J M | + | [[Category: Bynum, J M]] |
| - | [[Category: Fletterick, R J | + | [[Category: Fletterick, R J]] |
| - | [[Category: Ingraham, H A | + | [[Category: Ingraham, H A]] |
| - | [[Category: Juzumiene, D | + | [[Category: Juzumiene, D]] |
| - | [[Category: Krylova, I N | + | [[Category: Krylova, I N]] |
| - | [[Category: Moore, J | + | [[Category: Moore, J]] |
| - | [[Category: Sablin, E P | + | [[Category: Sablin, E P]] |
| - | [[Category: Waitt, G M | + | [[Category: Waitt, G M]] |
| - | [[Category: Willson, T M | + | [[Category: Willson, T M]] |
| - | [[Category: Xu, R X | + | [[Category: Xu, R X]] |
[[Category: Co-repressor peptide]] | [[Category: Co-repressor peptide]] | ||
[[Category: Ligand]] | [[Category: Ligand]] | ||
Revision as of 06:36, 25 December 2014
Mouse SF-1 LBD
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