1ujj
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ujj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ujj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJJ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jwf|1jwf]], [[1jwg|1jwg]], [[1ujk|1ujk]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jwf|1jwf]], [[1jwg|1jwg]], [[1ujk|1ujk]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujj RCSB], [http://www.ebi.ac.uk/pdbsum/1ujj PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujj RCSB], [http://www.ebi.ac.uk/pdbsum/1ujj PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref> [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Kametaka, S | + | [[Category: Kametaka, S]] |
| - | [[Category: Kawasaki, M | + | [[Category: Kawasaki, M]] |
| - | [[Category: Shiba, T | + | [[Category: Shiba, T]] |
| - | [[Category: Shibata, M | + | [[Category: Shibata, M]] |
| - | [[Category: Uchiyama, Y | + | [[Category: Uchiyama, Y]] |
| - | [[Category: Waguri, S | + | [[Category: Waguri, S]] |
| - | [[Category: Wakatsuki, S | + | [[Category: Wakatsuki, S]] |
[[Category: Adaptor protein]] | [[Category: Adaptor protein]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Protein transport-hydrolase complex]] | [[Category: Protein transport-hydrolase complex]] | ||
[[Category: Protein-peptide complex]] | [[Category: Protein-peptide complex]] | ||
Revision as of 06:54, 25 December 2014
VHS domain of human GGA1 complexed with C-terminal peptide from BACE
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