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2xkx
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xkx' size='340' side='right' caption='[[2xkx]], [[Resolution|resolution]] 22.90Å' scene=''> | <StructureSection load='2xkx' size='340' side='right' caption='[[2xkx]], [[Resolution|resolution]] 22.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKX OCA]. <br> | + | <table><tr><td colspan='2'>[[2xkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKX FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tq3|1tq3]], [[1rgr|1rgr]], [[1iu2|1iu2]], [[1jxm|1jxm]], [[1kjw|1kjw]], [[1tp3|1tp3]], [[1be9|1be9]], [[1bfe|1bfe]], [[1qlc|1qlc]], [[1iu0|1iu0]], [[1jxo|1jxo]], [[1tp5|1tp5]], [[2xky|2xky]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tq3|1tq3]], [[1rgr|1rgr]], [[1iu2|1iu2]], [[1jxm|1jxm]], [[1kjw|1kjw]], [[1tp3|1tp3]], [[1be9|1be9]], [[1bfe|1bfe]], [[1qlc|1qlc]], [[1iu0|1iu0]], [[1jxo|1jxo]], [[1tp5|1tp5]], [[2xky|2xky]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkx RCSB], [http://www.ebi.ac.uk/pdbsum/2xkx PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Self-directed assembly and clustering of the cytoplasmic domains of inwardly rectifying Kir2.1 potassium channels on association with PSD-95.,Fomina S, Howard TD, Sleator OK, Golovanova M, O'Ryan L, Leyland ML, Grossmann JG, Collins RF, Prince SM Biochim Biophys Acta. 2011 Jul 5;1808(10):2374-2389. PMID:21756874<ref>PMID:21756874</ref> | Self-directed assembly and clustering of the cytoplasmic domains of inwardly rectifying Kir2.1 potassium channels on association with PSD-95.,Fomina S, Howard TD, Sleator OK, Golovanova M, O'Ryan L, Leyland ML, Grossmann JG, Collins RF, Prince SM Biochim Biophys Acta. 2011 Jul 5;1808(10):2374-2389. PMID:21756874<ref>PMID:21756874</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Collins, R F | + | [[Category: Collins, R F]] |
| - | [[Category: Fomina, S | + | [[Category: Fomina, S]] |
| - | [[Category: Golovanova, M | + | [[Category: Golovanova, M]] |
| - | [[Category: Grossmann, J G | + | [[Category: Grossmann, J G]] |
| - | [[Category: Howard, T D | + | [[Category: Howard, T D]] |
| - | [[Category: Leyland, M L | + | [[Category: Leyland, M L]] |
| - | [[Category: Prince, S M | + | [[Category: Prince, S M]] |
| - | [[Category: Ryan, L O | + | [[Category: Ryan, L O]] |
| - | [[Category: Sleator, O K | + | [[Category: Sleator, O K]] |
[[Category: Membrane associated guanylate kinase]] | [[Category: Membrane associated guanylate kinase]] | ||
[[Category: Scaffold protein]] | [[Category: Scaffold protein]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 07:04, 25 December 2014
Single particle analysis of PSD-95 in negative stain
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