This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2khn
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KHN FirstGlance]. <br> | <table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KHN FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [http://www.ebi.ac.uk/pdbsum/2khn PDBsum], [http://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [http://www.ebi.ac.uk/pdbsum/2khn PDBsum], [http://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 16: | Line 18: | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton, T B | + | [[Category: Acton, T B]] |
| - | [[Category: Everett, J K | + | [[Category: Everett, J K]] |
| - | [[Category: Foote, E L | + | [[Category: Foote, E L]] |
| - | [[Category: Garcia, E | + | [[Category: Garcia, E]] |
| - | [[Category: Ghosh, A | + | [[Category: Ghosh, A]] |
| - | [[Category: Janjua, H | + | [[Category: Janjua, H]] |
| - | [[Category: Mills, J L | + | [[Category: Mills, J L]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Shastry, R | + | [[Category: Shastry, R]] |
| - | [[Category: Szyperski, T | + | [[Category: Szyperski, T]] |
| - | [[Category: Xiao, R | + | [[Category: Xiao, R]] |
| - | [[Category: Zhang, Q | + | [[Category: Zhang, Q]] |
[[Category: Cell junction]] | [[Category: Cell junction]] | ||
[[Category: Cell projection]] | [[Category: Cell projection]] | ||
| Line 40: | Line 44: | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Nesgc]] | [[Category: Nesgc]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Sh3 domain]] | [[Category: Sh3 domain]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Synapse]] | [[Category: Synapse]] | ||
[[Category: Synaptosome]] | [[Category: Synaptosome]] | ||
Revision as of 07:06, 25 December 2014
NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.
| |||||||||||
Categories: Homo sapiens | Acton, T B | Everett, J K | Foote, E L | Garcia, E | Ghosh, A | Janjua, H | Mills, J L | Montelione, G T | Structural genomic | Shastry, R | Szyperski, T | Xiao, R | Zhang, Q | Cell junction | Cell projection | Endocytosis | Gft nmr | High throughput | Human intersectin-1 | Membrane | Nesgc | Phosphoprotein | PSI, Protein structure initiative | Sh3 domain | Signaling protein | Synapse | Synaptosome
