1sn1

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1sn1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SN1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1sn1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SN1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sn4|1sn4]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sn4|1sn4]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sn1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sn1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sn1 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sn1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sn1 RCSB], [http://www.ebi.ac.uk/pdbsum/1sn1 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SCX1_MESMA SCX1_MESMA]] This alpha-like toxin binds voltage-dependently sodium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals and insects. Is active on Nav1.4/SCN4A and Nav1.5/SCN5A. Acts as a cardiotoxin. Is 6-fold more toxic than BmK-M2.<ref>PMID:11322948</ref> <ref>PMID:12705833</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Mesobuthus martensii]]
[[Category: Mesobuthus martensii]]
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[[Category: He, X L.]]
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[[Category: He, X L]]
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[[Category: Li, H M.]]
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[[Category: Li, H M]]
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[[Category: Liu, X Q.]]
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[[Category: Liu, X Q]]
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[[Category: Wang, D C.]]
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[[Category: Wang, D C]]
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[[Category: Zeng, Z H.]]
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[[Category: Zeng, Z H]]
[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
[[Category: Scorpion]]
[[Category: Scorpion]]
[[Category: Sodium channel inhibitor]]
[[Category: Sodium channel inhibitor]]
[[Category: Toxin]]
[[Category: Toxin]]

Revision as of 07:09, 25 December 2014

STRUCTURE OF SCORPION NEUROTOXIN BMK M1

1sn1, resolution 1.70Å

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